Not with a FusionAuth policy, but you could enforce it just by checking the user during login, as twoFactorEnabled is an attribute of the user.

There's also this github issue which you may want to vote up: https://github.com/FusionAuth/fusionauth-issues/issues/763

Not within the FusionAuth OAuth2 workflows, but you could prompt the user to do this after login.

@denisskaletti Thanks for feedback. I removed your link because it seemed like spam. We welcome useful links that are about using FusionAuth, please check out the blog category and post there.